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GS Paper IUPSC Prelims 2010
Health & Medicine
Question No. 407Interactive Test Mode
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+2-0.66

Q407. Widespread resistance of malarial parasite to drugs like chloroquine has prompted attempts to develop a malarial vaccine to combat malaria. Why is it difficult to develop an effective malaria vaccine?

Widespread resistance of malarial parasite to drugs like chloroquine has prompted attempts to develop a malarial vaccine to combat malaria. Why is it difficult to develop an effective malaria vaccine?

Select the correct option below (or cross out options to eliminate)
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Official Answer Key & Detailed Solution

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Official UPSC Answer KeyUPSC Prelims 2010 • Science and Technology

Correct Answer: Option (B) — Man does not develop immunity to malaria during natural infection

Concept & Option Breakdown

Standard Reference Verified
  • Option (b) is correct: A major obstacle to malaria vaccine development is that natural exposure does not confer sterile, long-lasting immunity. The complex multi-stage lifecycle of Plasmodium and continuous antigenic variation across its stages (sporozoite, merozoite, gametocyte) allow the parasite to evade human immune surveillance and establish repeated infections.
  • Option (c) is false: Vaccines are routinely produced against viruses (e.g., polio, measles) and protozoans.
Elimination Heuristic & Exam Approach

Vaccines rely on mimicking natural immunity. When natural infection itself does not produce sterilizing immunity due to high antigenic variability, vaccine design becomes exceptionally difficult.

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Question Specifications & Syllabus Mapping

Examination & YearUPSC Civil Services Preliminary Examination 2010 (Q407)
Paper & Marking SchemeGS Paper I • 2 Marks (-0.66 Negative for incorrect response)
Syllabus Subject & TopicScience and Technology → Health & Medicine
Official Answer KeyOption (B) — Man does not develop immunity to malaria during natural infection

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Frequently Asked Questions — UPSC Prelims 2010 Q407

What is the official answer for UPSC Prelims 2010 GS Paper I Question 407 (Science and Technology)?

The official UPSC answer key for this 2010 Science and Technology (Health & Medicine) question is Option (B): "Man does not develop immunity to malaria during natural infection". Correct attempts carry 2 Marks with -0.66 Negative penalty for wrong answers.

Which UPSC Prelims syllabus topic does this 2010 question belong to?

This question belongs to GS Paper I under the subject "Science and Technology" and micro-topic "Health & Medicine". You can explore all repeated questions from Health & Medicine in Acme AI's 3D Prelims PYQ Realm or practice 50 full-length and sectional tests in the APT Prelims Test Series.

How can I solve this Health & Medicine UPSC Prelims question using option elimination?

Vaccines rely on mimicking natural immunity. When natural infection itself does not produce sterilizing immunity due to high antigenic variability, vaccine design becomes exceptionally difficult.

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